Uterine Ichthyosis Associated With a High-Grade Squamous Lesion: A Case Report

Uterine ichthyosis is a rare condition characterized by the extensive replacement of the endometrial surface with keratinized squamous epithelium. While generally benign, it can be associated with premalignant or malignant lesions, making its management critical. Here, we present a case of a 66-year-old patient diagnosed with uterine ichthyosis, highlighting the presence of high-grade dysplasia within the metaplastic squamous epithelium. This finding emphasizes the necessity for careful evaluation and appropriate surgical treatment to rule out potential associated neoplasms. Given the rarity of uterine ichthyosis and its implications for patient management, further research is warranted to establish clear guidelines for diagnosis and treatment. This case underscores the importance of ongoing clinical vigilance and interdisciplinary collaboration in managing patients with this condition.