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Reflux disease and congenital laryngomalacia in neonates: A Kids' Inpatient Database analysis

Vraj P Shah1, Aman M Patel1, Praneet C Kaki1

  • 1Department of Otolaryngology-Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA.

Laryngoscope Investigative Otolaryngology
|November 11, 2024
PubMed

Insights

Congenital laryngomalacia (CLM) with reflux disease (RD) leads to poorer outcomes in neonates. These infants experienced longer hospital stays, higher costs, and more procedures compared to those without RD.

Area of Science:

  • Neonatal care
  • Pediatric otolaryngology
  • Gastroenterology

Background:

  • Congenital laryngomalacia (CLM) is the most frequent cause of stridor in newborns.
  • CLM is often linked to reflux disease (RD), including gastroesophageal and newborn esophageal reflux.

Purpose of the Study:

  • To investigate how reflux disease (RD) affects the management and outcomes of neonates diagnosed with congenital laryngomalacia (CLM).

Main Methods:

  • Utilized the 2016 Kids' Inpatient Database (KID) to identify neonates with CLM (ICD-10: Q31.5).
  • Identified RD status, procedures, and complications using ICD-10 codes.
  • Performed univariate and multivariable analyses to ascertain statistical associations.

Main Results:

  • Of 2212 neonates with CLM, 26.45% had RD. Patients with RD had significantly higher total charges and longer lengths of stay.
  • Neonates with RD underwent more diagnoses, procedures, and experienced a longer wait for their first procedure.
  • RD was associated with increased odds of laryngoscopy, bronchoscopy, and ventilator use, but not tracheotomy or mortality.

Conclusions:

  • Congenital laryngomalacia (CLM) is frequently associated with reflux disease (RD) in neonates.
  • Neonates with CLM and comorbid RD exhibit significantly poorer health outcomes, including increased healthcare utilization and intervention rates.
Abstract

Keywords:
congenital laryngomalaciahead and neck surgeryneonatepediatricreflux disease

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