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Advances in Microengineered Platforms for Skin Research.

Sireesh Kumar Teertam1,2, Vijayasaradhi Setaluri1,2,3, Jose M Ayuso1,2,4

  • 1Department of Dermatology, University of Wisconsin-Madison, Wisconsin, USA.

JID Innovations : Skin Science From Molecules to Population Health
|November 11, 2024
PubMed
Summary

Microfluidic skin-on-a-chip models offer advanced human skin research platforms. These physiologically relevant models overcome limitations of animal studies for developing new dermatology therapeutics.

Keywords:
In vitro cultureMicrofluidicsOrgan-on-a-chipSkin models

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Area of Science:

  • Dermatology and Bioengineering
  • In Vitro Modeling

Background:

  • Human skin's barrier and sensory functions are vital; disruptions cause disorders.
  • Animal models have limitations for human skin disease research.
  • Physiologically relevant human skin models are crucial for therapeutic development.

Purpose of the Study:

  • To review state-of-the-art microfluidic models for skin research.
  • To discuss the potential and challenges of skin-on-a-chip technologies.
  • To provide a future research roadmap in this field.

Main Methods:

  • Utilizing microfluidic technologies to create organ-on-chip devices.
  • Mimicking critical human skin architecture and physiological features.
  • Controlling fluid flow for precise cell and molecular distribution.

Main Results:

  • Microfluidic platforms enable multilayered in vitro skin models.
  • These models offer superior control over nutrient and drug distribution.
  • Applications include studying cellular crosstalk, migration, mechanobiology, microbiome interactions, vascular biology, and wound healing.

Conclusions:

  • Skin-on-a-chip technologies show promise for dermatology.
  • Microfluidic platforms enhance in vitro skin research capabilities.
  • Further research is needed to fully realize the potential of these advanced models.