Related Experiment Video
Updated: Jun 7, 2025
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Clinical and Biochemical Profiles of Hospitalized Patients with Hypercalcaemia from a Tertiary Care Centre in North
Aman Kumar1, Deepak Khandelwal2, Lovely Gupta3
1Department of Medicine, Maharaja Agrasen Hospital, Punjabi Bagh, New Delhi, India.
Insights
The study found primary hyperparathyroidism is the most common cause of hypercalcaemia in hospitalized Indian patients. Hypercalcaemia presents significant complications and mortality, necessitating awareness of changing patterns.
Area of Science:
- Endocrinology
- Nephrology
- Internal Medicine
Background:
- The prevalence and causes of hypercalcaemia in hospitalized Indian patients are not well-documented.
- Existing studies on hypercalcaemia profiles in Indian hospital settings are limited.
- A changing pattern of hypercalcaemia in hospitalized patients in India is suspected.
Purpose of the Study:
- To prospectively evaluate the clinical and biochemical profile of hospitalized patients with hypercalcaemia.
- To identify the common causes and complications of hypercalcaemia in a tertiary care center in North India.
Main Methods:
- Prospective assessment of clinical and biochemical profiles of 91 hospitalized patients with sustained hypercalcaemia.
- Investigations were conducted as per institutional protocol.
- Data analysis of collected patient information.
Main Results:
- The most frequent causes of hypercalcaemia were primary hyperparathyroidism (41.76%) and malignancy (15.38%).
- Common symptoms included nausea and anorexia; dehydration was the most frequent sign.
- Complications included acute kidney injury (45.05%) and acute pancreatitis (15.38%), with a 6.59% mortality rate.
Conclusions:
- Clinicians must recognize the evolving patterns of hypercalcaemia in hospital settings.
- Hypercalcaemia in hospitalized patients is linked to substantial morbidity and mortality.
- Further large-scale prospective studies are required to elucidate changing hypercalcaemia trends in India.
Abstract:
Background and aims: The profile of hypercalcaemia in hospitalized patients in India seems to be changing. However, studies evaluating the profile of hypercalcaemia in hospitalized settings in India are extremely limited. This prospective study aims to evaluate the clinical and biochemical profile of hospitalized patients with hypercalcaemia from a tertiary care centre in north India. Materials and methods: Clinical and biochemical profiles of subjects with hypercalcaemia detected during hospitalization/hospitalized with hypercalcaemia were assessed. A total of 91 subjects with sustained hypercalcaemia, who were eligible, underwent further investigation as per the institutional protocol and the data collected were analyzed. Results: The mean age of participants was 57.88 ± 14.23 years, with 62.64% of participants being females. The most common symptoms were nausea and anorexia, which were observed in all patients. The most common clinical sign was dehydration, which was observed in 32.97% of subjects. Primary hyperparathyroidism was the most common cause (41.76%), followed by suspected or confirmed malignancy/solid tumours in 15.38% of subjects. Other causes were advanced chronic liver disease (10.99%), multiple myeloma (9.89%), vitamin D toxicity (8.79%), granulomatous disorders (2.20%) and drug-i nduced disorders (1.10%). Forty-one subjects (45.05%) developed acute kidney injury and 14 subjects (15.38%) developed acute pancreatitis as a complication. Six subjects (6.59%) died during the course of hospitalization because of either primary disease or other secondary complications. Conclusions: Clinicians should be aware of changing patterns of hypercalcaemia in a hospital setting. Hypercalcaemia in hospitalized patients is associated with significant complications and mortality. Further large-scale prospective studies are needed to understand the changing pattern of hypercalcaemia in hospitalized patients from India.
More Related Videos
10:38Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
Published on: January 16, 2019
11:30A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Related Concept Videos
01:21Skeleton and Calcium Homeostasis
01:30Acute Pancreatitis II: Clinical Manifestations and Management
00:59The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
00:51Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.