Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Randomized Experiments01:13

Randomized Experiments

6.7K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
6.7K
Causality in Epidemiology01:21

Causality in Epidemiology

321
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
321
Study Design in Statistics01:15

Study Design in Statistics

7.8K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasonic-assisted encapsulation of lemongrass essential oil in HP-β-CD: Optimization, characterization, and application for mango preservation.

Ultrasonics sonochemistry·2025
Same author

Effects of Fertilizer Application on Growth and Stoichiometric Characteristics of Nitrogen, Phosphorus, and Potassium in Balsa Tree (<i>Ochroma lagopus</i>) Plantations at Different Slope Positions.

Plants (Basel, Switzerland)·2025
Same author

A mechanism-driven failure causality modeling approach for mechanical systems combining causal ordering theory and Ishikawa diagram.

Scientific reports·2025
Same author

The P4HB/LGALS3BP/NF-kB axis promotes the progression of MIA to IAC in lung adenocarcinoma.

Scientific reports·2025
Same author

Remote Patient Monitoring for Global Emergencies: Case Study in Patients With COVID-19.

JMIR formative research·2025
Same author

RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis.

Acta pharmaceutica Sinica. B·2025

Related Experiment Video

Updated: Jun 7, 2025

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

1.8K

Causal relationship between hypertension and ischemic stroke: A two-sample Mendelian randomization study.

Wenhao Zhang1, Yuhua Li2, Mengying Pang3

  • 1The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.

Brain Circulation
|November 11, 2024
PubMed
Summary

Essential hypertension significantly increases the risk of small-vessel ischemic stroke (IS). This genetic study confirms hypertension as a key risk factor for IS, highlighting the need for blood pressure management.

Keywords:
HypertensionMendelian randomizationischemic stroke

More Related Videos

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

1.1K
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

4.7K

Related Experiment Videos

Last Updated: Jun 7, 2025

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

1.8K
Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

1.1K
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

4.7K

Area of Science:

  • Genetics
  • Cardiovascular Epidemiology
  • Neurology

Background:

  • Ischemic stroke (IS) is a leading global health burden.
  • Hypertension is a known risk factor for IS, but findings vary.
  • Genetic data can clarify the hypertension-IS association.

Purpose of the Study:

  • To assess the causal association between hypertension and ischemic stroke risk.
  • To utilize a Mendelian randomization (MR) framework for robust analysis.
  • To investigate specific hypertension types and their link to small-vessel IS.

Main Methods:

  • Employed a two-sample Mendelian randomization (MR) approach.
  • Analyzed three hypertension traits: essential, gestational, and preexisting.
  • Utilized genetic susceptibility data from IEU-POENGWAS for small-vessel IS risk.

Main Results:

  • A strong association was found between essential hypertension and small-vessel IS.
  • Genetic susceptibility to gestational and preexisting hypertension also linked to small-vessel IS.
  • Congenital hypertension explained these associations in multivariate analyses.

Conclusions:

  • Hypertension is confirmed as an independent risk factor for ischemic stroke.
  • Essential hypertension elevates small-vessel IS risk approximately sixfold per SD increase.
  • Findings support hypertension management for IS prevention.