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DRAMP 4.0: an open-access data repository dedicated to the clinical translation of antimicrobial peptides

Tianyue Ma1, Yanchao Liu1, Bingxin Yu1

  • 1School of Life Science and Technology, China Pharmaceutical University, Nanjing 211100, P.R. China.

Nucleic Acids Research
|November 11, 2024
PubMed

Insights

The Data Repository of Antimicrobial Peptides (DRAMP) 4.0 now includes crucial stability and toxicity data for antimicrobial peptides (AMPs). This update aims to overcome challenges in developing AMPs for multidrug-resistant infections.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Bioinformatics

Background:

  • Antimicrobial peptides (AMPs) show promise for treating multidrug-resistant bacterial infections.
  • Clinical progression of AMPs is hindered by poor stability and hemolytic/cytotoxic properties.

Purpose of the Study:

  • To update the Data Repository of Antimicrobial Peptides (DRAMP) with enhanced stability and toxicity data.
  • To facilitate the development of safer and more effective AMPs.

Main Methods:

  • Incorporated new annotations for serum and protease stability.
  • Updated hemolytic and cytotoxic information based on experimental validation.
  • Expanded the DRAMP database with new entries and categories.

Main Results:

  • DRAMP 4.0 contains 30,260 entries, including 8,001 new additions.
  • Detailed experimental data on hemolytic activity (2,891 entries) and cytotoxicity (2,674 entries) are now available.
  • The repository includes stability data for 110 entries and expanded entries for 179 peptides.

Conclusions:

  • DRAMP 4.0 provides a comprehensive resource for AMP research, addressing key challenges in their development.
  • The updated data repository supports the identification and optimization of AMPs for therapeutic applications.

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