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Updated: Jun 7, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
CORUM in 2024: protein complexes as drug targets
Ralph Steinkamp1, George Tsitsiridis1, Barbara Brauner1
1Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstr. 1, Neuherberg D-85764, Germany.
The CORUM 5.0 database now includes drug effects on mammalian protein complexes, expanding its utility for drug discovery and network medicine research. This update links 725 drug targets to 1975 literature-documented instances of drug-protein complex interactions.
Area of Science:
- Biochemistry and Molecular Biology
- Pharmacology
- Bioinformatics
Background:
- Mammalian protein complexes play crucial roles in cellular processes.
- Understanding drug interactions with protein complexes is vital for drug efficacy.
- The CORUM database provides curated information on protein complexes.
Purpose of the Study:
- To update and expand the CORUM database with the latest information on mammalian protein complexes.
- To systematically investigate and integrate data on the impact of drugs on protein complexes.
- To enhance the utility of CORUM for pharmacological research and network medicine.
Main Methods:
- Manual curation of protein complex data for CORUM 5.0.
- Integration of drug target information from DrugCentral.
- Literature mining to identify drug-protein complex interactions.
Main Results:
- CORUM 5.0 contains 7193 manually curated mammalian protein complexes, the largest dataset available.
- 1975 instances of drug effects on protein complex formation/function were identified from literature.
- The database now links 725 protein drug targets with approved drugs and known mechanisms of action.
Conclusions:
- CORUM 5.0 represents a significant upgrade, offering the most comprehensive resource on mammalian protein complexes.
- The inclusion of drug-protein complex interactions enhances understanding of drug mechanisms and efficacy.
- This expanded resource is poised to advance network medicine and pharmacological research.
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