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Erythroderma in the elderly.

Toshiyuki Yamamoto1

  • 1Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

The Journal of Dermatology
|November 11, 2024
PubMed
Summary
This summary is machine-generated.

Erythroderma, a severe skin inflammation, presents as widespread redness and can stem from various conditions. This review explores its characteristics in the elderly and novel therapeutic strategies.

Keywords:
Th2deck‐chair signinflammagingpapulo‐erythrodermasenile atopic dermatitis

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Erythroderma is a critical, generalized skin inflammation resulting from diverse underlying diseases.
  • It manifests as widespread erythema, often accompanied by lymphadenopathy, fever, and chills.

Purpose of the Study:

  • To review the distinct characteristics of erythroderma in the elderly population.
  • To discuss emerging therapeutic approaches for erythroderma.

Main Methods:

  • Literature review of erythroderma causes, clinical presentation, and pathogenesis.
  • Analysis of studies focusing on elderly patients and novel treatments.

Main Results:

  • Erythroderma can be triggered by eczema, psoriasis, drug reactions, lymphoma, and other conditions, with idiopathic cases common.
  • The 'deck-chair sign' is a notable clinical feature, though not entirely specific.
  • A Th2-dominant immune response involving IL-4/IL-13 is implicated in erythroderma's etiology.

Conclusions:

  • Erythroderma in the elderly may be considered late-onset atopic dermatitis or a distinct entity.
  • Targeting Th2-related molecules presents a promising therapeutic avenue.