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DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

Nucleic Acid Structure

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

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Related Experiment Video

Updated: May 12, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Stepwise Assembly of DNA Nanostructures in a Surface-Based Method.

Huangchen Cui^1,2, Yaqi Wang^1,2, Linfeng Yang^1,2

¹School of Life Sciences, Tsinghua University, Beijing 100084, China.

|November 11, 2024

Summary

This study introduces a surface-based method for stepwise DNA origami assembly, enabling precise control over complex nanostructure formation. This approach enhances programmability and controllability for hierarchical DNA self-assembly.

Keywords:

DNA nanotechnology DNA origami stepwise assembly strand displacement surface reaction

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Last Updated: May 12, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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Published on: May 8, 2015

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

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Published on: September 27, 2019

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Published on: June 26, 2020

Area of Science:

Nanotechnology
Biotechnology
Materials Science

Background:

Hierarchical assembly of DNA nanostructures enables complex superstructures.
Precise control over hierarchical nanostructure fabrication remains a challenge.

Purpose of the Study:

To present a surface-based method for stepwise assembly of DNA origami nanostructures.
To demonstrate enhanced programmability and controllability in DNA self-assembly.

Main Methods:

Utilized magnetic beads and glass slides as solid supports.
Employed a surface-based strategy for hierarchical assembly of preformed DNA origami units.

Main Results:

Achieved stepwise hierarchical assembly of DNA origami nanostructures.
Demonstrated improved programmability and controllability through surface anchoring.

Conclusions:

The surface-based method offers enhanced control for DNA nanostructure assembly.
This strategy has potential as a general and standardized methodology for DNA nanostructures and beyond.