Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Biomimetic Single-Atom Nanozyme With a Substrate Pocket for Accurate and Continuous Sweat Glucose Monitoring.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Tryptamine from wake-active monoaminergic neurons regulates sleep homeostasis.

Nature neuroscience·2026

Same author

Quercetin regulates lipid metabolism and inflammatory microenvironment of microglia after spinal cord injury through activating the butyrate-FFAR2/AMPK/TFEB gut-brain axis signaling pathway.

International immunopharmacology·2026

Same author

Catalytic and regulatory basis of tRNA t<sup>6</sup>A modification by the KEOPS complex.

Nature communications·2026

Same author

Correction to "Hydrogen Bond-Assisted Two-Component Lipid Nanoparticles for Spleen-Specific mRNA Delivery".

Journal of the American Chemical Society·2026

Same author

The 2025 Westlake Autumn Symposium for Al Proteomics and Virtual Cell.

Genomics, proteomics & bioinformatics·2026

Same journal

Physiology-guided Self-supervised Learning for Simultaneous Dual-Tracer PET Separation.

IEEE transactions on medical imaging·2026

Same journal

Informed-Exploration Reinforcement Learning for Automated Virtual Coronary Intervention Planning.

IEEE transactions on medical imaging·2026

Same journal

4D Reconstruction of Fetal Left Ventricle from Echocardiography via 2.5D Radial Segmentation and Graph-Fourier Reconstruction.

IEEE transactions on medical imaging·2026

Same journal

Generalised Medical Phrase Grounding.

IEEE transactions on medical imaging·2026

Same journal

EndoLRMGS: Combining Large Reconstruction Modelling and Gaussian Splatting for Complete Endoscopic Scene Reconstruction.

IEEE transactions on medical imaging·2026

Same journal

A Neural-Analytical Fusion Scatter Correction Method for Multi-Source CT Using Equivalent High-Order Scatter.

IEEE transactions on medical imaging·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 7, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

Published on: November 30, 2022

Randomness-Restricted Diffusion Model for Ocular Surface Structure Segmentation.

Xinyu Guo, Han Wen, Huaying Hao

IEEE Transactions on Medical Imaging

|November 11, 2024

Summary

This summary is machine-generated.

This study introduces a novel diffusion model for segmenting ocular surface structures, improving accuracy for diagnosing conditions like dry eye disease and meibomian gland dysfunction.

More Related Videos

Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates

Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates

Published on: March 7, 2017

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Related Experiment Videos

Last Updated: Jun 7, 2025

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

Application of Deep Learning-Based Medical Image Segmentation via Orbital Computed Tomography

Published on: November 30, 2022

Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates

Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates

Published on: March 7, 2017

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Area of Science:

Ophthalmology
Medical Imaging
Artificial Intelligence

Background:

Ocular surface diseases are prevalent globally, necessitating accurate segmentation of ocular structures for diagnosis and treatment.
Current automated segmentation methods for ocular structures are limited, facing challenges like obscured boundaries and the need for multiple models.
A unified, one-model-fits-all approach for ocular surface segmentation is highly desirable for clinical applications.

Purpose of the Study:

To develop a novel, unified deep learning model for segmenting multiple ocular surface structures.
To address challenges in automated ocular surface segmentation, including inconspicuous boundaries and glare.
To improve the accuracy and efficiency of ocular structure segmentation for clinical decision-making.

Main Methods:

Introduction of a randomness-restricted diffusion model for multi-structure ocular surface segmentation.
Development of a time-controlled fusion-attention module (TFM) to manage information flow and constrain the generation process.
Implementation of a low-frequency consistency filter and a novel loss function to reduce model uncertainty and error accumulation.

Main Results:

The proposed model successfully segmented seven distinct ocular surface structures.
The method demonstrated superior performance compared to existing dedicated ocular surface and general medical image segmentation techniques.
Validation on two clinical datasets confirmed the model's utility in applications like meibomian gland dysfunction grading and dry eye diagnosis.

Conclusions:

The developed randomness-restricted diffusion model offers an effective solution for multi-ocular surface structure segmentation.
This approach overcomes limitations of previous methods, providing a versatile tool for ophthalmological research and clinical practice.
The model shows significant potential for improving the diagnosis and management of ocular surface diseases.