Inhalation toxicity studies with boron trifluoride

An acute study of boron trifluoride (BF3) in rats indicated the 4-hr LC50 to be 1.21 mg/liter. In a 2-week study, all animals exposed to 180 mg/m3 died prior to the sixth exposure, rats exposed at concentrations of 66 and 24 mg/m3 showed clinical signs of respiratory irritation, body weight gain depressions, increased lung weights, and depressed liver weights. Histopathology showed necrosis and pyknosis of the proximal tubular epithelium of the kidneys. This effect was limited to the high-concentration exposure group. Based on the results of these studies, Fischer 344 rats were exposed 6 hr/day, 5 days/week for 13 weeks to a respirable, liquid aerosol of BF3 at concentrations of 0, 2.0, 6.0, and 17 mg/m3. One rat in the high exposure group died. The most significant finding in this group was necrosis of the proximal tubular epithelium of the kidneys. Other observations noted during the study included dried material around the nose and mouth, rales and excessive lacrimation, reversible depression of serum total protein and globulin concentrations, and increases in urinary, serum, and bone fluoride amounts. In the lower exposure groups, findings of respiratory irritation were minimal. All observations occurred in a dose-related pattern. Based on this study, exposure to BF3 at 17 mg/m3 resulted in renal toxicity, while exposure at 6 mg/m3, although showing elevations of fluoride amounts, did not result in a toxic response.