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Potential Cognitive Decline Linked to Electronegative L5 in Type 2 Diabetes: A Holo-Hilbert Spectral Analysis
Ping-Song Chou1,2,3,4,5, Mei-Yueh Lee6,7,8, Wen-Sheng Chang9
1Department of Neurology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan.
Neuroendocrinology
|November 11, 2024
Summary
Elevated L5 in LDL-C is linked to higher risks of cognitive decline in type 2 diabetes patients. This study highlights L5 as a biomarker and HHSA as an innovative tool for assessing brain function in T2DM.
Area of Science:
- Neuroscience
- Endocrinology
- Biochemistry
Background:
- Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cognitive impairment.
- Low-density lipoprotein cholesterol (LDL-C) subfractions may play a role in T2DM-related cognitive dysfunction.
Purpose of the Study:
- To investigate the effect of L5, an electronegative LDL-C subfraction, on cognitive function in patients with T2DM.
- To explore the relationship between L5 levels, cognitive performance, and neural activity using Holo-Hilbert spectral analysis (HHSA).
Main Methods:
- Cross-sectional study of 68 T2DM patients (normal cognition, mild cognitive impairment (MCI), Alzheimer disease (AD)).
- Cognitive assessment using the Cognitive Abilities Screening Instrument.
- Development and application of Holo-Hilbert spectral analysis (HHSA) for electroencephalography (EEG) signal analysis.
Main Results:
- Higher L5 percentage in LDL-C (L5%) was independently associated with increased risks of MCI and AD in T2DM patients.
- A negative correlation was found between serum L5% and cognitive performance, especially concentration, in MCI patients.
- Elevated serum L5% correlated with increased low-frequency and decreased high-frequency neural oscillations in MCI patients.
Conclusions:
- L5 is a potential biomarker for cognitive impairment in T2DM.
- EEG/HHSA offers an innovative approach to assess cognitive function in T2DM.
- L5 may impact frontal lobe function, contributing to concentration deficits, with its effect varying by neurodegeneration stage.
Keywords:
ElectroencephalographyElectronegative low-density lipoprotein cholesterolHolo-Hilbert spectral analysisL5Mild cognitive impairmentMore Related Videos
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