JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in patients with actinic keratosis

  • 0Department of Dermatology, Copenhagen University Hospital, Bispebjerg, 2400 Copenhagen NV, Denmark.
Photodiagnosis and Photodynamic Therapy +

|

November 11, 2024

|

November 11, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

A prebiotic and panthenol cream (DC) significantly improved skin tolerance and accelerated healing after daylight photodynamic therapy (dPDT) for actinic keratosis (AK). The cream enhanced patient comfort without compromising dPDT treatment efficacy.

Area Of Science

  • Dermatology
  • Photodynamic Therapy
  • Cosmeceuticals

Background

  • Daylight photodynamic therapy (dPDT) for actinic keratosis (AK) can cause local skin reactions (LSR), impacting patient quality of life and treatment acceptance.
  • Investigating supportive topical treatments is crucial to mitigate post-procedural side effects and improve patient experience.

Purpose Of The Study

  • To evaluate the efficacy of a prebiotic and panthenol-containing Dermocosmetic Cream (DC) in reducing LSR following dPDT for AK.
  • To assess the impact of DC on skin healing, tolerance, and overall treatment outcomes.

Main Methods

  • A randomized controlled, intra-individual trial involving 20 patients with AKs on the face or décolleté.
  • Symmetrical treatment areas received artificial dPDT, followed by either DC application twice daily for 14 days or no cream (No-DC).
  • Outcomes measured included clinical LSR scores, erythema, crusting, AK clearance rate, and photoaging assessment.

Main Results

  • DC significantly reduced LSR severity on Days 2, 7, and 14 post-dPDT compared to No-DC (p<0.011).
  • Objective measurements showed decreased erythema and faster crusting resolution with DC use (p<0.045).
  • No significant difference in AK clearance rate was observed, but DC improved skin texture and dyspigmentation by Day 30.

Conclusions

  • A prebiotic and panthenol-containing DC significantly enhances tolerance and accelerates healing for up to 14 days after dPDT.
  • DC improves patient comfort without negatively affecting the therapeutic efficacy of dPDT for actinic keratosis.
  • This cosmeceutical offers a promising adjunctive therapy to improve the patient experience following dPDT.

Keywords: