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Cycloaddition of Butadiene with Perfluoroethylene: Prediction of a Periselectivity Switch under Pressure

Mohammed Loukili1,2, Ivan Rivilla1,3,4, Fernando P Cossio3

  • 1Donostia International Physics Center, Paseo Manuel de Lardizabal 4, 20018 Donostia-San Sebastián, Spain.

The Journal of Organic Chemistry
|November 11, 2024
PubMed

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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