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NiFe Nanoalloy Electrocatalyst as a Coreaction Accelerator for Enhancing Biomarker Electrochemiluminescence Imaging
Yusheng Wu1, Lixin Xu1, Juan Yang1
1State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
Abstract:
The development of coreaction accelerators with excellent performance is crucial for improving electrochemiluminescence (ECL) performance. In this study, a NiFe nanoalloy electrocatalyst (NiFe-NAEC) was used as a coreaction accelerator to promote persulfate activation, resulting in a 44-fold increase in the ECL intensity of flower-like Zn-3,4,9,10-perylenetetracarboxylate (FL-Zn-PTC). Moreover, the synergistic combination of NiFe-NAEC and silver nanoparticles led to a 134-fold increase in the ECL intensity of FL-Zn-PTC, with a 6275% improvement in the ECL efficiency compared with a reference system containing Ru-bpy/K2S2O8. Consequently, a sensor was constructed for the visual detection of amino-terminal pro-brain natriuretic peptide. This sensor exhibited high sensitivity and provided intuitive results within a linear range from 0.01 to 1000 pg/mL, with a detection limit of 2.1 fg/mL. Overall, this study presents a strategy that integrates an electrocatalytic coreaction accelerator with synergistic enhancement to improve ECL performance. This approach has the potential to expand the range of emitter materials and advance ECL technology.
