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Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
Published on: May 24, 2016
[Neonatal myocarditis due to Coxsackie: case report and literature review]
Dagoberto Delgado-Franco1, Andrea Sierra-Sepúlveda2, Luis Guillermo Meave-Cueva3
1Centro Médico ABC, Departamento de Neonatología. Ciudad de México, México.
Insights
This study highlights Coxsackie virus as a cause of neonatal viral myocarditis. Early detection and prompt intervention are crucial for improving outcomes in affected newborns.
Area of Science:
- Neonatal Cardiology
- Pediatric Infectious Diseases
- Viral Myocarditis
Background:
- Viral myocarditis in neonates is a rare but serious condition.
- Coxsackie virus is a common etiological agent.
- High morbidity and mortality rates are associated with neonatal viral myocarditis.
Observation:
- A case of Coxsackievirus-induced myocarditis in a female newborn is detailed.
- Diagnostic modalities included echocardiogram, cardiac MRI, and biomarker analysis.
- A literature review identified 6 similar cases from 1962 to 2022.
Findings:
- Analysis of clinical presentation, diagnostics, treatment, and outcomes.
- Comparison of the presented case with historical cases.
- Understanding the natural progression and response to intervention.
Implications:
- Emphasizes the critical role of early diagnosis in neonatal viral myocarditis.
- Highlights optimal clinical practices for effective management.
- Underscores the necessity of prompt intervention to improve prognosis and reduce mortality.
Abstract:
This article aims to elucidate viral myocarditis in neonates, focusing on a case involving Coxsackie virus, in order to enhance early detection and treatment, and, therefore, mitigating the substantial morbidity and mortality associated with this condition. Our study details the clinical course of a female newborn with Coxsackievirus-induced myocarditis, who underwent diagnostic modalities such as echocardiogram, cardiac magnetic resonance, and serial biomarker analysis, all of which allowed us to outline the disease's natural progression and its response to intervention over time. Based on a literature review we identified 6 similar cases, spanning from 1962 to 2022. In this analysis we assessed clinical presentation, diagnostic methodologies, treatment strategies, and prognostic outcomes, drawing comparisons between our case and reported instances. The objective is to highlight optimal clinical practices for managing this pathology effectively. Furthermore, we approach the pivotal role of early diagnosis and its impact on disease prognosis. We emphasize that, though rare, viral myocarditis in neonates can lead to a high rate of mortality, which is why a prompt diagnosis and an appropriate intervention are imperative to improve the outcome.
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