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Pan-cancer landscape analysis of NOP58 and its oncogenic driving role in lung adenocarcinoma

  • 0Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Scientific Reports +

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November 11, 2024

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November 11, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

NOP58 ribonucleoprotein is overexpressed in many cancers, including lung adenocarcinoma (LUAD). This study shows NOP58 is a potential diagnostic biomarker and prognostic factor for LUAD, impacting tumor growth and immune cell infiltration.

Area Of Science

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background

  • Lung adenocarcinoma (LUAD) patients often have poor prognoses despite treatment advancements.
  • Identifying novel biomarkers for cancer diagnosis and prognosis is crucial.

Purpose Of The Study

  • To investigate the role of NOP58 ribonucleoprotein in pan-cancer analysis.
  • To validate the oncogenic significance of NOP58 in LUAD.
  • To explore NOP58 as a potential diagnostic and prognostic biomarker.

Main Methods

  • Bioinformatic analysis of NOP58 expression across various cancer types.
  • In vitro and in vivo functional assays in LUAD cell lines and mouse models.
  • Correlation analysis of NOP58 expression with clinical characteristics, TNM stage, and immune cell infiltration in LUAD.
  • Tissue microarray analysis of NOP58 expression in LUAD tissues.

Main Results

  • NOP58 was significantly overexpressed in multiple tumor types and demonstrated high diagnostic accuracy for 20 cancers.
  • In LUAD, NOP58 expression correlated with advanced TNM stage, pathologic stage, smoking status, and treatment outcomes.
  • Elevated NOP58 expression was linked to increased Th2 cell infiltration and decreased infiltration of CD8 T, cytotoxic, and Th1 cells.
  • Inhibition of NOP58 reduced LUAD cell proliferation, migration, and invasion, and suppressed tumor growth in vivo.
  • Higher NOP58 expression was observed in LUAD tumor tissues compared to adjacent normal tissues.

Conclusions

  • NOP58 serves as a promising pan-cancer diagnostic and prognostic biomarker.
  • NOP58 is an independent prognostic risk factor in LUAD.
  • Targeting NOP58 may offer a therapeutic strategy for LUAD.

Keywords:

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