Related Experiment Video
Updated: Jun 7, 2025
11:56
Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
Published on: November 11, 2017
15.3K
Rectified activity-dependent population plasticity implicates cortical adaptation for memory and cognitive functions
Hong Xie1,2, Kaiyuan Liu3,4, Dong Li5
1School of Artificial Intelligence Science and Technology, University of Shanghai for Science and Technology, Shanghai, China. hongxie@usst.edu.cn.
Communications Biology
|November 11, 2024
Summary
The brain
Area of Science:
- Neuroscience
- Computational Neuroscience
- Cognitive Science
Background:
- The neocortex continuously rewires due to learning and memory.
- Understanding population-level adaptation in the neocortex over time is crucial.
Purpose of the Study:
- To investigate neocortical population adaptation trends.
- To identify an intrinsic cortical adaptation mechanism.
Main Methods:
- Recording cellular activity in large-scale cortical populations.
- Exposing populations to neutral and conditioned environments.
- Analyzing neural activity changes between adjacent days.
Main Results:
- Identified Rectified Activity-Dependent Population Plasticity (RAPP).
- Previously active neurons show reduced activity but residual potentiation.
- Increased population variability correlates with prior activity.
- RAPP predicts decay of context-induced patterns and sparse memory traces.
Conclusions:
- RAPP is a general intrinsic cortical adaptation mechanism.
- Local inhibitory connections may underlie RAPP's residual potentiation.
- RAPP improves artificial neural network pattern recognition.
- RAPP contributes to long-lasting memory and cognitive functions.
More Related Videos
05:01Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
Published on: September 20, 2024
318
14:27Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
12.4K
Related Concept Videos
01:01Neuroplasticity
302
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
302
01:30Cognitive Development During Adulthood
58
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
58
01:14Role of Cerebellum and Prefrontal Cortex in Memory
374
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
374
01:35Long-term Potentiation
54.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
54.8K
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
98
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
98
01:03Long-term Depression
2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.5K