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Partial volume correction for Lu-177-PSMA SPECT.

Yibin Liu¹, Zhonglin Lu^1,2, Gefei Chen¹

¹Department of Electrical and Computer Engineering, Biomedical Imaging Laboratory (BIG), Faculty of Science and Technology, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China.

|November 11, 2024

Summary

This summary is machine-generated.

Partial volume effect (PVE) significantly impacts SPECT imaging accuracy. This study evaluated three partial volume correction (PVC) methods—recovery coefficient-PVC (RC-PVC), reblurred Van-Cittert (RVC), and iterative Yang (IY)—demonstrating that all PVC techniques enhance quantification in ¹⁷⁷Lu-PSMA-617 SPECT imaging.

Keywords:

177Lu-PSMA-617 Iterative Yang Partial volume correction Reblurred Van-Cittert Recovery coefficient SPECT/CT

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Area of Science:

Nuclear Medicine
Medical Imaging
Radiopharmaceutical Therapy

Background:

Limited spatial resolution in SPECT imaging causes partial volume effect (PVE).
PVE degrades the accuracy of quantitative SPECT imaging, impacting dosimetry.
¹⁷⁷Lu-PSMA-617 therapy requires accurate quantification for effective treatment monitoring.

Purpose of the Study:

To quantitatively evaluate the performance of three partial volume correction (PVC) methods.
To assess PVC methods in ¹⁷⁷Lu-PSMA-617 SPECT imaging using phantom and clinical data.
To compare recovery coefficient-PVC (RC-PVC), reblurred Van-Cittert (RVC), and iterative Yang (IY) for PVE correction.

Main Methods:

Utilized a geometrical phantom and 40 XCAT phantoms for simulation studies.
Generated noisy projections using SIMIND Monte Carlo code.
Analyzed sequential SPECT/CT imaging data from 10 patients undergoing ¹⁷⁷Lu-PSMA-617 therapy.

Main Results:

Significant PVE observed, with recovery coefficients (RCs) of 0.26 and 0.70 for 20 mm and 40 mm spheres, respectively.
RVC and IY improved RCs, while IY and RC-PVC showed better performance for tumor quantification compared to RVC.
All PVC methods demonstrated improvements in activity quantification accuracy, with varying effects on noise and artifacts.

Conclusions:

Partial volume effect substantially affects activity quantification in SPECT, particularly for smaller structures.
All evaluated partial volume correction methods enhance quantification accuracy in ¹⁷⁷Lu-PSMA-617 SPECT imaging.
The choice of PVC method may depend on the specific application, balancing accuracy with potential introduction of noise or artifacts.