Estimated glucose disposal rate is correlated with increased depression: a population-based study

Area of Science:

• Metabolic Health
• Mental Health
• Epidemiology

Background:

• Growing evidence links insulin resistance (IR) to depression.
• Estimated glucose disposal rate (eGDR) offers a noninvasive method to assess IR.
• The relationship between eGDR and depression in the general population requires further investigation.

Purpose of the Study:

• To investigate the correlation between eGDR and depression in a large, diverse adult population.
• To explore the potential mediating role of the atherogenic index of plasma (AIP) in this relationship.

Main Methods:

• Analysis of data from 28,444 adults in the NHANES (1999-2018).
• Utilized multivariate logistic regression, subgroup analyses, and restricted cubic splines to assess eGDR-depression correlation.
• Conducted mediation analysis to evaluate AIP's role.

Main Results:

• A significant linear negative correlation was observed between eGDR and depression (OR=0.913).
• Higher eGDR levels (eGDR6-8 and eGDR>8) were associated with reduced depression risk compared to lower levels (eGDR<4).
• AIP mediated 9.6% of the association between eGDR and depression, particularly in individuals with obesity.

Conclusions:

• eGDR demonstrates a linear negative correlation with depression.
• AIP acts as a mediator in the link between IR (as measured by eGDR) and depression.
• Strategies targeting IR management and AIP monitoring may help alleviate depression symptoms.