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Updated: Jun 7, 2025
High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
Published on: May 10, 2012
EPI proton resonant frequency temperature mapping at 0.5T in the brain: Comparison to single-echo gradient recalled
Diego F Martinez1, Curtis N Wiens2, Chad T Harris2
1The xMR Labs, Department of Physics and Astronomy, Western University, London, Ontario, Canada.
Purpose:
Evaluate the use of both single-echo gradient recalled echo (SE-GRE) and EPI approaches to creating temperature maps on a mid-field head-only scanner, both in vivo and on a tissue mimicking gel.
Methods:
Three 2D protocols were investigated (an SE-GRE, single-shot EPI, and an averaged single-shot EPI). The protocols used either a gradient recalled acquisition or an echo planar acquisition, with EPI parameters optimized for the longer at lower field-strengths. Phantom experiments were conducted to evaluate temperature tracking while cooling, comparing protocol to measurements from an optical fiber thermometer. Studies were performed on a 0.5T head only MR scanner. Temperature stability maps were produced in vivo for the various protocols to evaluate precision.
Results:
The use of an EPI protocol for thermometry improved temperature precision in a temperature control phantom and provided an 18% improvement in temperature measurement precision in vivo. Temperature tracking using a fast (<2 s) update rate EPI thermometry sequence provided a similar precision to the slower SE-GRE protocol.
Conclusion:
While SE-GRE PRF thermometry shows good performance, EPI methods offer improved tracking precision or update rate, making them a better option for thermometry in the brain at mid-field.
