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Updated: Jun 7, 2025

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Type I Interferon Drives a Cellular State Inert to TCR-Stimulation and Could Impede Effective T-Cell Differentiation

Dillon Corvino1, Martin Batstone2,3, Brett G M Hughes2,3

  • 1Tumor-Immunobiology, Institute for Experimental Oncology, University Hospital Bonn, Bonn, Germany.

European Journal of Immunology
|November 12, 2024
PubMed
Summary

Researchers discovered a novel CD8+ T-cell subset, termed interferon-stimulated genes (ISG)-enriched cells, in HPV-negative head and neck squamous cell carcinoma. These cells, though transcriptionally inert, may influence antitumor immunity and impact treatment strategies.

Keywords:
CD8+ T‐cellsHNSCC TILsType I IFNscRNAseqscTCRseq

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