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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

121
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
121
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

178
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
178

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Extraction of Plant-based Capsules for Microencapsulation Applications
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Microencapsulation techniques for developing cannabidiol formulations: a review.

Ariel Gustavo Garro1,2, Soledad Ravetti2,3, Sofía Gisella Brignone4

  • 1Ministerio de Producción, Ciencia e Innovación Tecnológica de la Provincia de Córdoba, Córdoba, CP 5004, Argentina.

Therapeutic Delivery
|November 12, 2024
PubMed
Summary
This summary is machine-generated.

Microencapsulation enhances the therapeutic potential of cannabidiol (CBD) by improving its poor bioavailability and water solubility. This technique offers a promising solution for optimizing CBD formulations and administration challenges.

Keywords:
cannabidiolcannabismicroencapsulationnatural productspharmaceutical technology

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Area of Science:

  • Pharmacology and Pharmaceutical Sciences
  • Biotechnology
  • Natural Product Chemistry

Background:

  • Cannabidiol (CBD), derived from Cannabis sativa L., exhibits therapeutic properties without psychoactive effects.
  • CBD interacts with the endocannabinoid system, influencing mood, pain, and immune responses.
  • Poor bioavailability and water solubility limit CBD's clinical efficacy and administration.

Purpose of the Study:

  • To review various microencapsulation techniques for CBD.
  • To analyze the advantages and limitations of different microencapsulation methods.
  • To explore the implications for optimizing CBD formulations.

Main Methods:

  • Comprehensive literature review of microencapsulation techniques for CBD.
  • Analysis of published data on CBD microencapsulation methods.
  • Evaluation of formulation optimization strategies.

Main Results:

  • Microencapsulation significantly improves CBD's bioavailability and solubility.
  • Various techniques like spray-drying, liposomal encapsulation, and nanoparticle formation are effective.
  • Each method presents unique advantages and limitations regarding scalability, cost, and encapsulation efficiency.

Conclusions:

  • Microencapsulation is a viable strategy to overcome CBD's formulation challenges.
  • Optimized microencapsulated CBD formulations hold significant promise for enhanced therapeutic delivery.
  • Further research is needed to refine methods for large-scale, cost-effective production.