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Published on: March 24, 2015
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Serum Direct Bilirubin as a Biomarker for Breast Cancer
Jinxi Hu1, Yangjun Cai1, Yijun Chen2
1Department of Oncological Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, People's Republic of China.
Breast Cancer (Dove Medical Press)
|November 12, 2024
Summary
Serum direct bilirubin (DB) is a significant risk factor for breast cancer. Elevated DB levels indicate a higher risk and show potential as a diagnostic marker for breast cancer detection.
Area of Science:
- Biochemistry
- Oncology
- Medical Diagnostics
Background:
- The role of serum total bilirubin (TB) and its subtypes, like serum direct bilirubin (DB), in cancer remains controversial.
- Previous research has not definitively established the association between serum DB and breast cancer risk or its diagnostic utility.
Purpose of the Study:
- To investigate the association between serum direct bilirubin (DB) levels and breast cancer.
- To assess the diagnostic utility of serum DB in breast cancer detection.
Main Methods:
- A cohort study involving 5299 newly diagnosed breast cancer patients and 10028 healthy controls.
- Logistic regression analysis to determine the relationship between serum DB and breast cancer.
- Receiver operating characteristic (ROC) curve analysis to evaluate the diagnostic accuracy of serum DB.
Main Results:
- Serum DB concentrations were significantly higher in breast cancer patients compared to healthy controls (P < 0.001).
- Serum DB was identified as an independent risk factor for breast cancer (OR=4.504, 95% CI: 4.200-4.831).
- The optimal cut-off value for diagnosing breast cancer was 2.75 μmol/L, with an AUC of 0.712, showing good specificity (77.0%) and NPV (77.8%).
Conclusions:
- Serum direct bilirubin (DB) is a confirmed risk factor for breast cancer.
- Serum DB demonstrates promising diagnostic potential for breast cancer.
- Serum DB may serve as a valuable serum molecular marker for breast cancer screening and diagnosis.
