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Invasive Candidiasis: A Promising Approach Using Jatropha Dioica Extracts and Nanotechnology

Carlos Fernández-Villascan1, Rosalba Patiño-Herrera1, Ivonne Patino1

  • 1Departamento de Ingeniería Química, Instituto Tecnológico de Celaya, Tecnológico Nacional de México, Av. Tecnológico y Antonio García Cubas Poniente #600, Celaya, Guanajuato, 38010, México.

Chemistry & Biodiversity
|November 12, 2024
PubMed

Insights

This study explores combining Jatropha dioica plant extracts with magnetite nanoparticles (MNPs) to combat Candida albicans infections. The Jatropha dioica ethanolic extract-MNP combination shows high antifungal activity at safe concentrations.

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Mycology

Background:

  • Candida albicans is an opportunistic pathogen causing infections.
  • Rising antifungal resistance necessitates novel therapeutic strategies.
  • Natural products and nanotechnology offer potential solutions.

Purpose of the Study:

  • To investigate the synergistic antifungal effects of Jatropha dioica extracts and magnetite nanoparticles (MNPs) against Candida albicans.
  • To evaluate the toxicity and efficacy of these combined materials.

Main Methods:

  • Preparation and characterization of Jatropha dioica aqueous (JdextAq) and ethanolic (JdextEt) extracts.
  • Synthesis and characterization of magnetite nanoparticles (MNPs).
  • Fourier-transform infrared spectroscopy (FTIR) to analyze metabolite-MNP interactions.
  • Antifungal inhibition assays against Candida albicans.
  • Cytotoxicity assessments on cell viability.

Main Results:

  • FTIR confirmed metabolite binding to MNPs at Fe2+ and Fe3+ sites.
  • MNPs (11±3 nm) were non-toxic at 500 μg/ml; JdextAq was cytotoxic at this concentration.
  • The JdextAq-MNP hybrid exhibited toxicity at low concentrations (50-250 μg/ml).
  • Both MNPs and JdextEt-MNPs demonstrated high inhibition rates (>97%) against C. albicans at safe concentrations.

Conclusions:

  • Jatropha dioica extracts combined with MNPs show significant potential as antifungal agents.
  • The JdextEt-MNP formulation is effective and non-toxic, offering a promising therapeutic strategy.
  • These findings contribute to developing new approaches against drug-resistant Candida albicans.
Keywords:
Antifungal activityCandida albicansJatropha dioicaMagnetic nanoparticles

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