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FRET Imaging in Three-dimensional Hydrogels
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Recent Development of Fibrous Hydrogels: Properties, Applications and Perspectives.

Wen Luo1, Liujiao Ren2, Bin Hu1

  • 1International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Henan Key Laboratory of Rare Earth Functional Materials, Zhoukou Normal University, Zhoukou, 466001, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 12, 2024
PubMed
Summary

Fibrous hydrogels offer enhanced mechanical properties and diverse functions. This review explores their assembly, mechanisms, and applications in advanced materials like sensors and tissue scaffolds.

Keywords:
ECM‐likeconductivityfibrous hydrogelsmechanicalstimulus

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Area of Science:

  • Materials Science
  • Biomaterials Engineering

Background:

  • Fibrous hydrogels (FGs) possess a 3D network structure from fibers and polymers.
  • Balancing mechanical properties and functionality remains a key challenge in FG development.

Purpose of the Study:

  • To review the advantages, assembly methods, and performance enhancement mechanisms of fibrous hydrogels.
  • To discuss FG applications in sensors, dressings, and tissue scaffolds.
  • To provide insights into future FG design and applications.

Main Methods:

  • Review of literature on fibrous hydrogel assembly techniques (e.g., fiber cross-linking, interfacial treatments, supramolecular assembly).
  • Analysis of mechanisms improving FG properties (conductivity, antimicrobial/anti-inflammatory activity, stimulus responsiveness, ECM-like structure).

Main Results:

  • FGs exhibit enhanced mechanical properties, conductivity, antimicrobial/anti-inflammatory effects, stimulus responsiveness, and ECM-like structures.
  • Assembly methods significantly influence FG functionalities.
  • Specific mechanisms like ion channels and in situ drug gelation enhance performance.

Conclusions:

  • Optimizing FG performance through synergistic effects enables applications in sensors, dressings, and tissue scaffolds.
  • Further research is needed to address challenges and unlock future potential of advanced FGs.