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Long-Range Proton Channels Constructed via Hierarchical Peptide Self-Assembly.

Semion Censor1, Jorge Vega Martin2, Ohad Silberbush1

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Researchers created long, peptide-based artificial nanochannels for efficient proton transport. These channels mimic natural systems, showing potential for energy storage, biomedicine, and bioelectronics applications.

Keywords:
molecular dynamic simulationspeptidesproton channelsproton transportself‐assembly

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Area of Science:

  • Biomimetic chemistry
  • Nanotechnology
  • Supramolecular chemistry

Background:

  • Natural proton channels are crucial for biological energy processes.
  • Mimicking these channels with artificial systems is a key challenge in nanotechnology.
  • Peptide self-assembly offers a promising route to create ordered nanostructures.

Purpose of the Study:

  • To design and fabricate peptide-based artificial nanochannels for efficient proton transport.
  • To investigate the self-assembly mechanism and structural properties of these peptide channels.
  • To evaluate the proton transport efficiency and compare it with natural systems.

Main Methods:

  • Hierarchical self-assembly of cyclic peptides into micrometers-long nanotubes.
  • Utilizing intermolecular aromatic interactions for nanotube alignment.
  • Incorporating titratable amino acid sidechains and counter ions within the nanochannels.

Main Results:

  • Successfully formed micrometers-long proton nanochannels via hierarchical peptide self-assembly.
  • Demonstrated efficient proton transport through hydrogen-bonded chains within the channels.
  • Achieved proton transfer rates comparable to natural protein channels over micrometer distances.
  • Enhanced proton flow density and rate through interaction with counter ions.

Conclusions:

  • Hierarchical peptide self-assembly provides a viable strategy for creating functional proton nanochannels.
  • These artificial channels exhibit biomimetic proton transport capabilities.
  • The recyclable and biocompatible nature of these systems suggests broad applicability in energy, medicine, and electronics.