[Hypopigmented mycosis fungoide. Case report]

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Hypopigmented mycosis fungoides (HMF) is a rare cutaneous T-cell lymphoma variant.
• It commonly affects children and presents as hypopigmented macules in non-sun-exposed areas.
• Diagnosis relies on histopathology and immunohistochemistry, with topical treatments as first-line therapy.

Observation:

• A 69-year-old female presented with a 7-year history of dermatosis affecting 35% of her body surface.
• Lesions were polymorphic hypochromic macules, some converging into larger plaques, with associated itching.
• Histopathology and immunohistochemistry confirmed stage IB HMF.

Findings:

• The patient received prednisone and phototherapy, resulting in a positive treatment response.
• This case highlights the importance of considering HMF in differential diagnoses.
• Limited knowledge dissemination about HMF can lead to delayed diagnosis and incorrect treatment.

Implications:

• Increased awareness of HMF is essential for early diagnosis and timely intervention.
• Improved understanding can enhance patient prognosis and prevent mismanaged care.
• Further research into HMF pathogenesis and treatment is warranted.