Detection of early renal perfusion changes by contrast-enhanced ultrasonography in dogs with preclinical myxomatous mitral valve disease
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Summary
This summary is machine-generated.Contrast-enhanced ultrasonography (CEUS) detects early renal perfusion changes in dogs with preclinical myxomatous mitral valve disease (MMVD) before intrarenal Doppler ultrasonography (IRD) shows abnormalities.
Area Of Science
- Veterinary Cardiology
- Renal Physiology
- Diagnostic Imaging
Background
- Prognosis of myxomatous mitral valve disease (MMVD) varies, with renal impairment as a known complication.
- Intrarenal Doppler ultrasonography (IRD) predicts cardiac and renal events but misses early preclinical MMVD changes.
- Contrast-enhanced ultrasonography (CEUS) may detect earlier renal perfusion alterations.
Purpose Of The Study
- To investigate if CEUS can detect earlier renal perfusion changes in dogs with preclinical MMVD compared to IRD.
- To compare CEUS findings with IRD indices in dogs across different stages of MMVD.
Main Methods
- Prospective, cross-sectional study involving 23 dogs with MMVD (stages B1 and B2) and 12 controls.
- Renal perfusion assessed using CEUS, measuring time-intensity curves for renal cortex and medulla rise times.
- IRD indices (resistance index, venous impedance index) were also measured and compared.
Main Results
- CEUS showed a longer cortical rise time in stage B2 MMVD dogs compared to controls.
- CEUS indicated a shortened medullary rise time in stage B2 MMVD dogs with right ventricular dysfunction.
- No significant changes were detected in IRD indices in dogs with preclinical MMVD.
Conclusions
- CEUS identified alterations in renal perfusion in dogs with preclinical MMVD.
- These changes were detectable even when IRD indices remained normal.
- CEUS demonstrates potential utility for evaluating renal perfusion in dogs with MMVD.
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