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Updated: Jun 7, 2025

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
Published on: January 7, 2022
Total Synthesis of Marformycins A and D
Avraz F Anwar1, Yassin M Elbatrawi1, David Degen2
1Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
None:
We report the synthesis of the antimicrobial cyclodepsipeptides marformycin A (1) and marformycin D (2) using a solid-phase approach. A scalable solution-phase synthesis of the γ-hydroxypiperazic acid subunit in 2, starting from cis-hydroxyproline, is also described. Structural analysis of 1 and its Leu-epi congener demonstrates conformational differences that may underlie their divergent antimicrobial activities. The described approach enables further development of conformation-activity relationships within this class of depsipeptide natural products.
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