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Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
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Epithelial Na+ Channels, Immune Cells, and Salt

Annet Kirabo1, Sepiso K Masenga2, Thomas R Kleyman3,4

  • 1Division of Clinical Pharmacology, Department of Medicine, Department of Molecular Physiology and Biophysics, Vanderbilt Center for Immunobiology, Vanderbilt Institute for Infection, Immunology and Inflammation and Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA.

Annual Review of Physiology
|November 12, 2024
PubMed
Summary

Epithelial Sodium Channels (ENaCs) in dendritic cells sense sodium levels, activating T cells and raising blood pressure. This pathway may contribute to human hypertension.

Keywords:
ENaCaldosteronedendritic cellshypertensionproteasesodium

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