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Updated: Jun 7, 2025

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

Cell-Free DNA in Hematologic Malignancies.

Joseph G Schroers-Martin¹, Ash A Alizadeh^1,2,3

¹Department of Medicine, Divisions of Hematology & Oncology, Stanford University Medical Center, Stanford, CA.

JCO Oncology Practice

|November 12, 2024

Summary

This summary is machine-generated.

Cell-free DNA (cfDNA) offers a non-invasive method for monitoring blood cancers like lymphomas, myeloma, and leukemias. This review explores cfDNA technologies and their clinical applications in hematologic malignancies.

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Area of Science:

Hematology
Oncology
Molecular Diagnostics

Background:

Cell-free DNA (cfDNA) analysis is established for solid tumors.
Molecular assessment in blood cancers typically relies on circulating tumor cells or bone marrow biopsies.
cfDNA presents an emerging, less invasive alternative for hematologic malignancies.

Purpose of the Study:

To review key technologies for cfDNA analysis in hematologic cancers.
To discuss current clinical data on cfDNA utilization in lymphomas, myeloma, and leukemias.
To highlight the potential of cfDNA for disease assessment independent of invasive procedures.

Main Methods:

Review of existing literature and clinical studies on cfDNA in hematologic malignancies.
Analysis of technological advancements in cfDNA detection and quantification.
Synthesis of clinical data regarding the application of cfDNA in lymphomas, myeloma, and leukemias.

Main Results:

cfDNA offers a promising approach for disease assessment and monitoring in hematologic cancers.
Key technologies are emerging for cfDNA analysis, enabling quantification independent of tumor burden.
Clinical data supports the growing role of cfDNA in managing lymphomas, myeloma, and leukemias.

Conclusions:

cfDNA is an emerging tool in hematology, complementing established methods.
Non-invasive cfDNA analysis holds significant potential for characterizing and surveilling blood cancers.
Further research and validation are ongoing to integrate cfDNA into routine clinical practice for hematologic malignancies.