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Understanding the Biology and Testing Techniques for Pharmacogenomics in Oncology: A Practical Guide for the
Nury M Steuerwald1,2, Sarah Morris3, D Grace Nguyen3
1Molecular Biology and Genomics Core Laboratory, Atrium Health Levine Cancer Institute, Charlotte, NC.
Abstract:
Pharmacogenomic (PGx) testing is a growing area of personalized medicine with demonstrated clinical utility in improving patient outcomes in oncology. PGx testing of pharmacogenes affecting drug pharmacokinetics, pharmacodynamics, and response can help inform drug selection and dosing of several anticancer therapies and supportive care medications. Several PGx testing techniques exist including polymerase chain reaction (PCR), MassARRAY, microarray, and sequencing. This review article provides a clinician-friendly guide of these techniques. Understanding the advantages, limitations, ideal use, and potential clinical applications of each platform can help clinicians choose the appropriate PGx testing platform for specific use cases.
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