Nanomaterial-based electrochemical biosensors as tools for detecting the tumor biomarker miR-21

MicroRNAs (miRNAs) are noncoding RNA transcripts with myriad physiologically important regulatory roles in the human body. These miRNAs have also recently emerged as promising biomarkers for the diagnosis of particular cancers. Conventional miRNA detection strategies, however, are characterized by many limitations. As electrochemical biosensors offer advantages including low costs, high levels of sensitivity, and amenability to miniaturization, they hold great promise as an alternative approach to miRNA detection. Nanomaterials are commonly used in the context of electrochemical sensor production, and this review provides an overview of the use of various carbon nanomaterials, metallic nanomaterials, metal-organic frameworks, magnetic nanomaterials, and conductive polymer nanocomposites to modify electrochemical biosensors in order to facilitate the detection of miRNA-21. A range of materials and detection methods for particular cancer types are discussed herein highlighting the superior sensitivity and specificity of these analytical strategies., which allow for the stable and reproducible detection of miRNAs in clinical samples. Ultimately, this review demonstrates the promising clinical prospects of these modified electrochemical biosensors as tools for early cancer diagnosis and the prognostic evaluation of affected patients.