Related Experiment Video

Updated: Jun 7, 2025

Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity
06:39

Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity

Published on: September 1, 2023

2.5K

Gut commensal bacteria Parabacteroides goldsteinii-derived outer membrane vesicles suppress skin inflammation in

Dandan Su1, Manchun Li1, Yuedong Xie1

  • 1School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|November 12, 2024
PubMed

Insights

Gut bacteria outer membrane vesicles (OMVs) can travel from the gut to inflamed skin, reducing psoriasis-like symptoms. Local injection of these vesicles also effectively treats skin inflammation.

Area of Science:

  • Microbiology
  • Immunology
  • Dermatology

Background:

  • Gut microbiota-derived extracellular vesicles (EVs) are key in bacteria-host interactions.
  • The role of EVs in modulating skin inflammation, particularly psoriasis, is largely unknown.
  • Psoriasis involves complex immune dysregulation and skin inflammation.

Purpose of the Study:

  • To investigate the therapeutic potential of Parabacteroides goldsteinii-derived outer membrane vesicles (Pg OMVs) for skin inflammation.
  • To explore the gut-skin axis pathway for OMV delivery to inflamed skin.
  • To evaluate local administration of Pg OMVs for sustained anti-inflammatory effects.

Main Methods:

  • Mass production of Parabacteroides goldsteinii-derived outer membrane vesicles (Pg OMVs).
  • Oral administration of Pg OMVs in psoriasis-like mouse models.
  • Subcutaneous injection of Pg OMVs encapsulated in a thermosensitive hydrogel (PF-127).

Main Results:

  • Orally administered Pg OMVs reached inflamed skin via the gut-skin axis.
  • Pg OMVs treatment reduced epidermal hyperplasia and inflammatory cell infiltration in skin lesions.
  • Both oral and local Pg OMV administration ameliorated skin and systemic inflammation in psoriasis-like mice.

Conclusions:

  • Gut microbiota-derived OMVs can effectively target inflamed skin, offering a novel therapeutic strategy.
  • Pg OMVs demonstrate significant immunomodulatory effects, reducing skin inflammation.
  • This study presents OMVs as a promising alternative to live bacteria for treating inflammatory skin diseases.
Keywords:
Gut-skin axisImmunoregulationOuter membrane vesiclesParabacteroides goldsteiniiPentadecanoic acidSkin inflammatory diseases

More Related Videos

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

14.5K
Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages08:34

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages

Published on: February 22, 2017

11.1K

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.6K
Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
3
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
954
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
388