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Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model
Published on: December 9, 2018
Protective effects and mechanism of quercetin from Rhododendron dauricum against cerebral ischemia-reperfusion injury
Fang Fang1, Siwei Bao1, Danxia Chen1
1Department of Pharmacy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
Methods:
This study seeks to identify the bioactive compounds within Rhododendron dauricum and explore potential mechanisms for treating cerebral I/R injury through a comprehensive analysis employing network pharmacology, complemented by experimental validation.
Results:
The core targets associated with quercetin in the treatment of cerebral I/R injury are TNF-α, IL-6, IL-1β, and AKT1. Notably, we propose for the first time that its mode of action primarily involves the inhibition of the TNF-α/RhoA/ROCK2 pathway.
Conclusion:
Our findings reveal that quercetin emerges as a pivotal bioactive component of Rhododendron dauricum in the context of cerebral I/R injury treatment.
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