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Related Experiment Video

Updated: May 8, 2026

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

Core-shell upconversion nanoparticles with suitable surface modification to overcome endothelial barrier.

Chao Lu¹, Jianying Ouyang², Jin Zhang^3,4

¹Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON, N6A 5B9, Canada.

|November 12, 2024

Summary

This summary is machine-generated.

Modified upconversion nanoparticles (UCNPs) with N, N-trimethyl chitosan (TMC) effectively overcome endothelial barriers for improved bioimaging delivery. This cationic modification enhances nanoparticle transport across biological tissues.

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Area of Science:

Materials Science
Biomedical Engineering
Nanotechnology

Background:

Upconversion nanoparticles (UCNPs) offer promising near-infrared (NIR) to visible light conversion for bioimaging.
Tissue barriers impede effective nanoparticle delivery for in vivo applications.
Surface modification of nanoparticles is crucial for overcoming biological barriers.

Purpose of the Study:

To develop core-shell UCNPs modified with N, N-trimethyl chitosan (TMC) to enhance endothelial barrier penetration.
To evaluate the transport efficiency and biocompatibility of TMC-modified UCNPs.
To assess the potential of these modified UCNPs for improved bioimaging delivery.

Main Methods:

Synthesis of core-shell UCNPs (NaGdF4:Yb3+,Tm3+@SiO2) and surface modification with poly(ethylene glycol) (PEG) and TMC.
Characterization using XRD, TEM, and zeta potential measurements.
In vitro assessment of endothelial barrier integrity (TEER, tight junction proteins) and nanoparticle transport across a model endothelial barrier.

Main Results:

TMC modification significantly increased the zeta potential of UCNPs@SiO2-PEG, indicating enhanced cationic properties.
TMC-modified UCNPs demonstrated no significant toxicity to HUVECs up to 250 µg/mL.
The transport percentage of TMC-modified UCNPs across the in vitro endothelial barrier model was up to 4.56%, significantly higher than unmodified UCNPs.

Conclusions:

Core-shell UCNPs surface-modified with TMC can effectively overcome endothelial barriers.
The enhanced transport ability suggests improved potential for targeted delivery in bioimaging applications.
TMC modification represents a viable strategy to enhance nanoparticle penetration through biological barriers.