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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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  1. Home
  3. Pan-cancer Landscape Of Dctpp1 And Preliminary Exploration Of Dctpp1 In Renal Clear Cell Carcinoma.
  1. Home
  3. Pan-cancer Landscape Of Dctpp1 And Preliminary Exploration Of Dctpp1 In Renal Clear Cell Carcinoma.

Related Experiment Video

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
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Pan-cancer landscape of DCTPP1 and preliminary exploration of DCTPP1 in renal clear cell carcinoma.

Hongze Li1, Yan Xu1, Jingjing Shan2

  • 1Department of Urology, The First Hospital of China Medical University, Shenyang, 110001, China.

Scientific Reports
|November 12, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

dCTP pyrophosphatase 1 (DCTPP1) shows varied expression across 33 cancers, acting as a diagnostic biomarker. High DCTPP1 levels correlate with better patient survival and immunotherapy response, suggesting its therapeutic potential.

Keywords:
DCTPP1ImmunotherapyPan-cancerRenal clear cell carcinomaTumor microenvironment

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Area of Science:

  • Oncology
  • Immunology
  • Biomarker Discovery

Background:

  • dCTP pyrophosphatase 1 (DCTPP1) is implicated in cancer progression but lacks comprehensive multi-omics characterization.
  • Its role in tumor prognosis and the immune microenvironment remains largely unexplored across diverse cancer types.

Purpose of the Study:

  • To conduct a pan-cancer multi-omics analysis of DCTPP1.
  • To investigate DCTPP1's prognostic significance, its association with the tumor immune microenvironment, and its predictive value for immunotherapy and drug sensitivity.

Main Methods:

  • Utilized multi-omics data from 33 cancer types.
  • Performed comprehensive bioinformatic analyses including expression profiling, pathway enrichment, and immune correlation.
  • Experimentally validated DCTPP1's function in renal clear cell carcinoma.

Main Results:

  • DCTPP1 exhibits differential expression and diagnostic significance across cancers.
  • DCTPP1 expression correlates with tumor mutational burden (TMB) and microsatellite instability (MSI).
  • Higher DCTPP1 levels are associated with improved patient survival and response to immunotherapy, including immune checkpoint inhibitors (ICIs).
  • DCTPP1 knockdown suppressed invasion and proliferation in renal clear cell carcinoma models.

Conclusions:

  • DCTPP1 serves as a potential pan-cancer biomarker for prognosis and predicting immunotherapy response.
  • DCTPP1 influences the tumor immune microenvironment and holds therapeutic potential.
  • Further research into DCTPP1's mechanisms in tumor infiltration and cancer therapy is warranted.