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Cardiac amyloidosis. Therapeutic and diagnostic difficulties with reference to two different forms of the disease

H Leinonen, S Pohjola-Sintonen

    Acta Medica Scandinavica
    |January 1, 1986
    PubMed

    Insights

    Primary cardiac amyloidosis can present with angina or heart failure. Autopsy revealed amyloid deposition in coronary arteries and myocardium, highlighting diagnostic challenges of this rare heart condition.

    Area of Science:

    • Cardiology
    • Pathology
    • Medical Imaging

    Background:

    • Primary cardiac amyloidosis is a rare infiltrative disease affecting the heart.
    • Early diagnosis and treatment are crucial but often challenging.

    Observation:

    • Case 1: Male patient with angina, normal coronary angiogram, and autopsy-confirmed intramural coronary artery amyloidosis.
    • Case 2: Male patient with heart failure, septal hypertrophy, pericardial effusion, and autopsy-confirmed myocardial amyloidosis.

    Findings:

    • Amyloid deposition in intramural coronary arteries can cause angina without typical ischemic changes.
    • Diffuse myocardial uptake on Technetium-99m pyrophosphate scintigraphy suggests cardiac amyloidosis.

    Implications:

    • These cases highlight the diverse presentations and diagnostic difficulties of cardiac amyloidosis.
    • Further research into diagnostic markers and therapeutic strategies for cardiac amyloidosis is warranted.

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