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Related Experiment Video

Updated: Jun 7, 2025

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

Brain morphometry in transient global amnesia: a triangulated analysis approach.

Micaela Anahi Hernández¹, Hernán Chaves², Ricardo Francisco Allegri¹

¹Fleni, Department of Cognitive Neurology, Buenos Aires, Argentina.

Dementia & Neuropsychologia

|November 13, 2024

Summary

This study found no significant structural brain differences in patients experiencing transient global amnesia (TGA). Findings suggest TGA may stem from network dysfunction rather than anatomical changes, impacting memory temporarily.

Keywords:

Amnesia Magnetic Resonance Imaging Transient Global

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Last Updated: Jun 7, 2025

Three-Dimensional Shape Modeling and Analysis of Brain Structures

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Published on: November 14, 2019

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

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A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

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Published on: July 2, 2014

Area of Science:

Neuroscience
Neurology
Radiology

Background:

Transient global amnesia (TGA) is a temporary memory disturbance with unknown causes.
Previous brain imaging studies on TGA patients yielded inconsistent results regarding structural changes.

Purpose of the Study:

To investigate brain morphometry in TGA patients.
To determine if structural alterations are present in individuals with TGA.

Main Methods:

A case-control study included 50 TGA patients and 50 healthy controls.
All participants underwent 3T structural MRI scans.
Voxel-based morphometry (VBM), region-based morphometry (RBM), and surface-based morphometry (SBM) were employed.

Main Results:

No statistically significant structural brain differences were detected between TGA patients and controls after applying multiple corrections.
VBM, RBM, and SBM analyses did not reveal consistent volumetric changes.

Conclusions:

The study's findings contradict previous research suggesting volumetric changes in TGA.
The results support the hypothesis of network dysfunction, not structural alterations, as a potential mechanism for TGA.
This research indicates that structural changes are unlikely to be a predisposing factor for TGA.