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Multifaceted role of TRIM28 in health and disease

Mazaher Maghsoudloo1, Khatere Mokhtari2, Behdokht Jamali3

  • 1Key Laboratory of Epigenetics and Oncology the Research Center for Preclinical Medicine Southwest Medical University Luzhou Sichuan China.

Medcomm
|November 13, 2024
PubMed

Insights

Tripartite Motif (TRIM) protein TRIM28 regulates gene expression and chromatin remodeling. This review explores TRIM28

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Biology

Background:

  • The Tripartite Motif (TRIM) family, including TRIM28, is crucial for cellular regulation.
  • TRIM28 interacts with KRAB-Zinc Finger (KRAB-ZNF) proteins to modulate gene expression and chromatin.
  • The exact roles of TRIM28 in health and disease are still under investigation.

Purpose of the Study:

  • To review the diverse functions of TRIM28 in health and disease.
  • To elucidate TRIM28's dual role in cancer progression as a tumor promoter or suppressor.
  • To highlight TRIM28's involvement in DNA repair, cell cycle, and stem cell maintenance.

Main Methods:

  • Literature review of existing research on TRIM28.
  • Analysis of TRIM28's molecular mechanisms in various biological processes.
  • Examination of TRIM28's context-dependent functions in different cancer types.

Main Results:

  • TRIM28 plays a significant role in transcriptional regulation and chromatin remodeling.
  • TRIM28 exhibits context-dependent oncogenic or tumor-suppressive activities in cancer.
  • TRIM28 is implicated in DNA repair, cell cycle control, epithelial-to-mesenchymal transition, and stemness.

Conclusions:

  • TRIM28 is a versatile regulator with complex roles in health and disease.
  • Understanding TRIM28's multifaceted functions is key to developing novel therapeutic strategies.
  • TRIM28 presents a promising therapeutic target for cancer and other diseases.
Keywords:
DNA damage responseTRIM familyTRIM28cancer pathogenesiscancer therapytranscriptional regulation

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