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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Intestinal Permeability In Subjects With Rheumatoid Arthritis: A Critical Therapeutic Priority.

Thomas G Guilliams1, Jill L Weintraub2, Myles Spar3

  • 1Scientific Director, AndHealth, Columbus, Ohio; Founder and Director of the Point Institute, Stevens Point, Wisconsin; Adjunct Associate Professor, School of Pharmacy, University of Wisconsin-Madison.

Integrative Medicine (Encinitas, Calif.)
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PubMed
Summary
This summary is machine-generated.

Biomarkers of intestinal permeability, or leaky gut, are linked to rheumatoid arthritis. Targeting gut barrier function may help manage this immune-mediated inflammatory disease.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease (IMID) affecting joints.
  • Advances in RA therapy target downstream inflammatory mediators like cytokines and Janus Kinase (JAK) inhibitors.
  • Fewer advances address upstream triggers of IMIDs, such as intestinal hyperpermeability (leaky gut) and gut dysbiosis.

Purpose of the Study:

  • To review the association between intestinal permeability biomarkers and non-gastrointestinal IMIDs.
  • To highlight the gut-joint axis in conditions like rheumatoid arthritis.
  • To explore the potential of targeting gut barrier function in RA management.

Main Methods:

  • Narrative review of existing literature.
  • Discussion of immune-signaling pathways common to IMIDs.
  • Analysis of the link between gut health and systemic inflammation.

Main Results:

  • Intestinal hyperpermeability is an antecedent to various chronic conditions, including RA.
  • Biomarkers of intestinal permeability are frequently associated with non-gastrointestinal IMIDs.
  • The gut-joint axis is increasingly recognized in RA pathogenesis.

Conclusions:

  • Measures of intestinal permeability are relevant to rheumatoid arthritis.
  • Interventions targeting gut barrier function may aid RA patients.
  • Addressing gut health could be an adjunctive strategy for RA remission.