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A Multicenter Home-based Prehabilitation Intervention in Kidney Transplant Candidates
Elizabeth C Lorenz1, Amanda R Bonikowske2, Ashley C David-Van Meter2
1Section of Nephrology, Baylor College of Medicine, Houston, TX.
Transplantation Direct
|November 13, 2024
Summary
A home-based exercise program improved frailty in kidney transplant candidates. This 8-week intervention was feasible, safe, and acceptable, offering a promising prehabilitation strategy.
Area of Science:
- Nephrology
- Transplantation
- Geriatrics
Background:
- Frailty is a significant risk factor for adverse outcomes in kidney transplant candidates.
- Previous research showed benefits of a center-based exercise program for frailty in advanced chronic kidney disease.
- Adapting exercise interventions for home-based delivery is crucial for accessibility.
Purpose of the Study:
- To adapt a center-based exercise intervention for home delivery to kidney transplant candidates.
- To assess the feasibility, safety, and acceptability of this home-based exercise program.
- To gather preliminary data for future larger studies.
Main Methods:
- A prospective pilot study was conducted with kidney transplant candidates who were frail or prefrail.
- Participants received an individualized exercise prescription and 8 weekly phone calls.
- Feasibility was measured by retention rates, safety by adverse events, and acceptability by surveys.
Main Results:
- Fifteen participants were enrolled, with a median age of 64 years.
- Sixty percent of participants completed the 8-week home-based exercise intervention.
- No unanticipated adverse events were reported, and participants found the program beneficial.
Conclusions:
- A home-based 8-week exercise intervention is a feasible and safe prehabilitation strategy for kidney transplant candidates.
- The intervention was well-accepted by participants, indicating its potential for wider application.
- This pilot study provides essential data for designing future randomized controlled trials.
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