Effects of Maternal Obesity on Oxidative Parameters in Maternal and Cord Blood Samples

Aim The purpose of this study was to analyze oxidative stress parameters in maternal and cord blood samples from both obese and nonobese women. Methods Our study included 30 obese and 35 nonobese pregnant women aged 18-40. We analyzed and compared oxidative stress parameters, including thiol/disulfide balance markers (native thiol, total thiol, and disulfide), albumin, ischemia-modified albumin (IMA), myeloperoxidase (MPO), catalase, ceruloplasmin, and intracellular glutathione levels. Results The comparison of maternal blood oxidative stress parameters between obese and nonobese pregnant women showed significantly higher levels of disulfide, catalase (kU/L), and ceruloplasmin (U/L) in the obese group (p = 0.005, p = 0.001, p < 0.001, respectively). Similarly, in cord blood, disulfide (µmol/L), IMA, catalase (kU/L), and (U/L) levels were significantly higher in the obese group (p < 0.001, p = 0.049, p < 0.001, p = 0.023, respectively), while albumin levels were significantly higher in the nonobese group (p = 0.003). Conclusions Our results suggest a strong association between maternal obesity and increased oxidative stress in both mothers and their offspring. Elevated oxidative stress levels may contribute to adverse maternal and fetal clinical outcomes. Therefore, we conclude that maintaining healthy weight control during reproductive age is crucial for ensuring maternal and fetal well-being.