Lymphocyte percentage correlations for the Coulter S+IV

Area of Science:

• Hematology
• Clinical Laboratory Science
• Medical Technology

Background:

• Previous studies identified a statistically significant bias in lymphocyte enumeration using the Coulter S+II TM system.
• This bias was noted when comparing results to the Geometric Data Hematrak TM automated differential counting system.

Purpose of the Study:

• To evaluate lymphocyte enumeration accuracy with the updated Coulter S+IV TM system.
• To determine if the previously identified bias in lymphocyte counts has been resolved.

Main Methods:

• Correlation studies were performed comparing lymphocyte counts.
• Data was generated utilizing the Coulter S+IV TM automated cell counter.
• Results were compared against established automated differential counting systems.

Main Results:

• New data indicates the elimination of the previously observed bias in lymphocyte enumeration.
• The Coulter S+IV TM system demonstrates improved accuracy compared to the Coulter S+II TM.

Conclusions:

• The Coulter S+IV TM system has resolved the lymphocyte enumeration bias found in the Coulter S+II TM.
• This advancement improves the reliability of automated lymphocyte counting in clinical settings.