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Updated: Jun 7, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Pimarane diterpenoids: sources, structures and biological activities
Haiqiang Zhang1,2, Meng Li3, Ayi Lvha4
1Key Laboratory of Evaluation and Transformation of Traditional Chinese Medicine Under Hebei Provincial Administration of Traditional Chinese Medicine, Hebei Provincial Hospital of Chinese Medicine, Shijiazhang, P.R. China.
Abstract:
The pimarane diterpenoids, a widespread class of secondary metabolites, have been found in several dozens of plant species from various families and in organisms from other taxonomic groups. According to the different chiral centres, pimarane diterpenes can be divided into four types, including pimarane, isopimarane, ent-pimarane, and ent-isopimarane. Meanwhile, these compounds possessed many pharmacological activities, such as cytotoxic, anti-inflammatory, and antibacterial activities. Due to their notable structure and biological activities these substances have attracted interest in recent years. A comprehensive account of the structural diversity (368 structures, 117 references) and biological activities of pimarane diterpenes discovered from 2000 until 2023 is given in this review.
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