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Related Experiment Video

Updated: Jun 7, 2025

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Transcranial Direct Current Stimulation Combined With Repetitive Transcranial Magnetic Stimulation for Depression: A

Dongsheng Zhou1, Xingxing Li1,2,3, Shuochi Wei1

  • 1Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University (Ningbo Kangning Hospital), Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders, Ningbo, Zhejiang, China.

JAMA Network Open
|November 13, 2024
PubMed
Summary
This summary is machine-generated.

Combining transcranial direct current stimulation (tDCS) with repetitive transcranial magnetic stimulation (rTMS) significantly improved depression treatment outcomes. This combined therapy offers a more effective option for major depressive disorder (MDD) compared to individual treatments.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Trials

Background:

  • Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are established monotherapies for depression.
  • The combined efficacy of rTMS and tDCS for major depressive disorder (MDD) remains largely unexplored.

Purpose of the Study:

  • To evaluate the clinical effectiveness and safety of combining rTMS and tDCS versus individual or sham treatments in MDD patients.
  • To compare the outcomes of active tDCS + active rTMS, sham tDCS + active rTMS, active tDCS + sham rTMS, and sham tDCS + sham rTMS.

Main Methods:

  • A double-blind, sham-controlled randomized clinical trial involving 240 adult MDD patients.
  • Participants received 2 weeks of treatment, 5 times per week.
  • Interventions included combinations of active or sham tDCS (2-mA current to DLPFC) and active or sham rTMS (10 Hz to left DLPFC).

Main Results:

  • The active tDCS + active rTMS group demonstrated a significantly greater reduction in Hamilton Depression Rating Scale (HDRS-24) scores compared to all other groups.
  • Mean HDRS-24 score reduction was 18.33 in the combined active group versus 14.86 (sham tDCS + active rTMS), 9.21 (active tDCS + sham rTMS), and 10.77 (sham tDCS + sham rTMS).

Conclusions:

  • Combined tDCS and rTMS therapy is a more effective and safe treatment for major depressive disorder (MDD) than either modality alone.
  • This combination therapy represents a promising advancement in the non-invasive brain stimulation treatment landscape for MDD.