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Related Experiment Video

Updated: Jun 7, 2025

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Published on: January 12, 2017

Toe-Brachial Index Rise in Lymphedema Patients with Multilayer Bandage.

J E Trihan^1,2, S Mestre^3,4, I Quere^3,4

¹Vascular Medicine Unit, Cholet Hospital, Cholet, France.

|November 13, 2024

Summary

Multilayer compression bandaging (MLB) is key for lymphedema, but can harm patients with lower extremity artery disease (LEAD). This study found subclinical LEAD in over a quarter of lymphedema limbs, suggesting it

Keywords:

compression bandaging lower extremity artery disease (LEAD)lymphedema peripheral artery disease (PAD)toe-brachial index

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A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

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Published on: November 2, 2019

Area of Science:

Vascular Medicine
Lymphedema Management
Peripheral Artery Disease

Background:

Multilayer compression bandaging (MLB) is a primary lymphedema treatment.
MLB is contraindicated in patients with advanced lower extremity artery disease (LEAD).
The prevalence of LEAD in lymphedema patients is currently unknown.

Purpose of the Study:

To estimate the prevalence of LEAD (defined by toe-brachial index [TBI] < 0.7) in lymphedema patients.
To measure the evolution of TBI after 30 minutes of MLB.

Main Methods:

A 3-month cross-sectional study.
Included patients with lower extremity lymphedema.
Recorded demographic data, basal TBI (T=0min), and TBI after 30 min of MLB (T=30min).

Main Results:

27.6% of lymphedema limbs (n=8/29) had non-symptomatic LEAD (TBI < 0.7).
LEAD was associated with advanced age, severe stages, and longer lymphedema duration.
Median TBI significantly increased after MLB (0.81 to 0.96, p=0.004).

Conclusions:

Subclinical LEAD is prevalent in over a quarter of lymphedema limbs.
LEAD is underestimated in lymphatic pathologies.
MLB may improve TBI, but careful patient selection is crucial.