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  1. Home
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  5. Environmental Sciences
  7. Soil Sciences
  9. Soil Physics
  11. Assessing The Stereoselective Bioactivity And Biotoxicity Of Penthiopyrad In Soil Environment For Efficacy Improvement And Hazard Reduction

Assessing the stereoselective bioactivity and biotoxicity of penthiopyrad in soil environment for efficacy improvement and hazard reduction

Kuan Fang1, Tong Liu1, Guo Tian1

  • 1Tobacco Research Institute of Chinese Academy of Agricultural Sciences (CAAS), Qingdao 266101, PR China.

Journal of Hazardous Materials
|November 13, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

S-penthiopyrad exhibits significantly higher bioactivity and persistence in soil than R-penthiopyrad. This chiral pesticide enantiomer, S-penthiopyrad, shows greater potential for agricultural development due to its distinct bioactivity and biotoxicity profiles.

Area of Science:

  • Environmental Chemistry
  • Agrochemical Science
  • Toxicology

Background:

  • Penthiopyrad is a widely used chiral pesticide in agriculture.
  • A comprehensive understanding of its stereoselective bioactivity and biotoxicity in soil ecosystems is lacking.

Purpose of the Study:

  • To investigate the stereoselective bioactivity of penthiopyrad against soil-borne pathogens.
  • To evaluate the stereoselective biotoxicity of penthiopyrad to non-target soil organisms.

Main Methods:

  • Assessed bioactivity against three soil-borne pathogens.
  • Investigated bioaccumulation and persistence in soil.
  • Analyzed effects on earthworm detoxification enzymes (GST, CarE, CYP450) and gene expression.
  • Examined protein binding affinities (COL6A, ACE, CYP450).
Keywords:
AlphaFold2Chiral pesticidesMolecular dockingRNA-seq

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Main Results:

  • S-penthiopyrad demonstrated significantly higher bioactivity (546x, 76x, 1.1x) against pathogens compared to R-penthiopyrad.
  • S-penthiopyrad showed greater soil persistence and bioaccumulation.
  • Both enantiomers induced earthworm apoptosis and intestinal damage, with S-penthiopyrad showing stronger effects.
  • Differential protein binding (COL6A/ACE for S-, CYP450 for R-) explains toxicity variations.

Conclusions:

  • Stereochemistry critically influences penthiopyrad's bioactivity and environmental fate.
  • S-penthiopyrad presents higher efficacy and persistence, alongside distinct toxicity mechanisms.
  • Understanding enantiomer-specific properties is crucial for developing safer and more effective agrochemicals.
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