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Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
Published on: June 30, 2023
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The association between heart failure and systemic inflammatory response index: A cross-sectional study
Yu Zheng1, Zixing Nie1, Yifan Zhang1
1First Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410007, China; Hunan University of Chinese Medicine, Yuelu District, Changsha, Hunan 410000, China.
Journal of the National Medical Association
|November 13, 2024
Summary
The systemic inflammatory response index (SIRI) is positively linked to heart failure (HF). This study found a significant linear association between higher SIRI levels and increased odds of HF, highlighting inflammation
Area of Science:
- Cardiology
- Inflammation Research
- Public Health
Background:
- The systemic inflammatory response index (SIRI) is a novel composite marker for systemic inflammation.
- Systemic inflammation is increasingly recognized as a key factor in the pathophysiology of heart failure (HF).
Purpose of the Study:
- To investigate the association between SIRI and the prevalence of heart failure (HF).
Main Methods:
- Cross-sectional analysis of 30,294 participants from the NHANES database (2001-2018).
- SIRI calculated using monocyte, neutrophil, and lymphocyte counts.
- Weighted multiple variable linear regression and restricted cubic splines used to assess linear and nonlinear relationships between SIRI and HF.
Main Results:
- A positive linear correlation was observed between SIRI and HF (OR=1.66; 95% CI, 1.21, 2.29).
- No significant nonlinear relationship between SIRI and HF was detected.
- The association remained consistent across subgroup analyses.
Conclusions:
- SIRI demonstrates a significant linear positive association with heart failure.
- Further prospective research is warranted to confirm these findings and explore clinical implications.
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